目的 为解决湿疹乳膏暴露过程中失水开裂的问题,对该制剂中保湿剂(甘油)的最佳用量进行筛选。方法 配制8份不同用量的甘油样品,测定不同温度,不同时间的失水百分率,建立每个温度下每组样品失水百分率随时间变化的动力学方程,求算失水速度常数,采用等级一致性检验法,比较不同温度下8份湿疹乳膏样品失水速度差别,得出保湿剂(甘油)的最优用量。结果 实验及统计分析结果表明,各样品在不同温度下的数学表达式皆为幂函数模型,方程的斜率即为失水速度常数。等级有一致性的倾向,即各温度下各样品的失水速度常数有显著性差异(P＜0.05),湿疹乳膏中保湿剂(甘油)用量为13.6%时等级和Ri最大,保湿效果最佳。结论 本实验筛选出在25～65 ℃内,失水速度最慢的湿疹乳膏甘油用量为13.6%。
Abstract
OBJECTIVE To determine the optimum amount of humectant (glycerin) in eczema cream to solve the water loss and cracking problem during storage. METHODS Eight eczema cream samples with different dosages of glycerol were prepared. The percentage of water loss was determined, and the dynamic equations at different temperatures for different times were established. The constant of water loss rate was calculated, the speed of water loss was compared for the eight samples with the method of test for grade consistency, and the optimal amount of humectant (glycerin) was determined. RESULTS The mathematical expressions for the samples at different temperatures all complied to power function model, and the constant of water loss rate was the slope of the equation. The rating tended to be consistent, which indicated that there were significant differences in the water loss rate constants of the samples at different temperatures (P<0.05). The grade summation of Ri and moisturizing effect tended to top when the dosage of moisturizer (glycerin) was 13.6% in eczema cream. CONCLUSION The optimal amount of glycerol in eczema cream is 13.6% with the lowest water loss in the temparature range of 25-65 ℃.
关键词
湿疹乳膏 /
失水百分率 /
失水速度常数 /
保湿剂 /
甘油 /
幂函数模型 /
等级一致性检验法
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Key words
eczema cream /
water loss percentage /
water loss rate constant /
humectant /
glycerin /
power function model /
method of test for grade consistency
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中图分类号：
R944
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参考文献
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脚注
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基金
国家科技部支撑计划(2008BAI53B042)
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